CB1 and CB2
There are a lot of cells in our brain. Those cells have tiny protein structures on their surface that are called receptors. These receptors accept neurotransmitters and cannabinoids, like THC and Anadamide. These receptors are in a class called G-protein receptors. G-Protein receptors are incredible. The CB1 receptor is the MOST abundant G-protein coupled receptor in the human brain!! G-protein receptors are involved in human disease and are a big interest to pharmaceutical companies because of it. These receptors are a part of the endocannabinoid system and are found all throughout the central nervous system and body. This is a complex system that has been under investigation since the 90's! CB1 and CB2 play a role in keeping the body functioning properly. This state of optimal function is called Homeostasis.
CB2 is another G-protein receptor that is found on the surface of cells in the brain, but also found throughout the body. CB2 can be found in the peripheral nervous system, the GI system and the immune system. Like CB1, CB2 also accept neurotransmitters and cannabinoids, like THC and a different endocannabinoid called 2-AG. These receptors are what you activate when you ingest cannabis. Activation of this system is of particular interest to the medical community due to its role in almost every human disease
is an endocannabinoid, which means we create it inside our body. It activates CB1 receptors and is the primary neurotransmitter for the CB2 receptor. It is found all over the central nervous system, 2-AG is being studied for its role in neuro protection and can play an important role in helping athletes and accident victims recover from traumatic brain injuries. 2-AG is present in the brain 170 times greater then AEA. 2-AG is broken down inside the body by a protein called MAGL-Monoacylglycerol lipase.
Ananda is Sanskrit means bliss or happiness. This neurotransmitter, fatty acid, was named this because it plays a big role in our mood. Said to mimic the action of THC it plays a big role in how we feel, when we eat, and how we behave. It binds to both CB1 and CB2. Anandamide could be a potential therapy for pain. A lot more research is needed on these endogenous compounds that exist inside our body, they seem to play a major role in our ability to fight disease and maintain homeostasis. AEA is broken down inside the body by a enzyme called FAAH-Fatty acid amide hydrolase. The inhibition of this enzyme is of interest because it allows the body to have more anandamide available.